He was soon in the lead with Leeds University student Tom Bishop leading the chase.
Pearson went further ahead with Leeds City's Simon Deakin establishing himself in second place.
Bishop held on well to take third place ahead of Longwood's Ian Mitchell, making a return to racing after injury.
Pearson, who missed the first race in the series, now has two victories.
With the best three performances to count in the four race series, Pearson must run in the final race next month to retain his title.
Leeds City again trounced the opposition with their six counters in the top nine places.
The women's race was won by Katie Walshaw (Holmfirth) who had almost half a minute to spare over Spenborough junior Jenny Walsh.
Walshaw, who led Holmfirth to a narrow team win over Leeds City, has won all three races and takes the League title without needing to contest the final race.
Susan Partridge (Leeds City) won the women's section in yesterday's Leeds Abbey Dash, finishing 68th overall in the massive field of over 6000. Partridge, who ran in the marathon at this year's European Championships, finished in 33:26.
Kenya's David Rudisha and Croatia's Blanka Vlasic have been named the male and female world athletes of the year, IAAF president Lamine Diack has announced. Beijing has been chosen to host the 2015 IAAF World Championships.