The former England centre, 30, hasn’t featured since last September as he recovers from major knee surgery.
But he is in the 19-man squad as improving Huddersfield seek a fourth successive win.
Interim head coach Chris Thorman, who is expected to remain in charge with Australian Simon Woolford still not arrived in the UK, said: “We’re as excited as anyone with Leroy coming back in.
He could potentially start. He's trained really well. He is super-critical of himself and doesn’t want to be underdone but I keep telling him he's ticked all the boxes in terms of the medical point of view, conditioning and S and C (strength and conditioning).
"I've told him he is available for selection from every department in the club but, Leroy being Leroy, he is his own worst critic and he's debating whether he’d be ready or not.
“All being well he’ll feature and with the momentum we’ve got at the moment now we can talk about Leroy as well as a real lift for everyone.
"Everyone sees not only his physical stature but what he’s done in the sport and for this club; we get a real leader of men back and leader in actions.
"It will be a real plus."
Daniel Smith also returns from injury with Sam Wood and Tyler Dickinson dropping out of the 19-man squad.
Meanwhile, Giants prop Matty English, 20, has been rewarded for his excellent form with a new deal that sees him stay at the club until the end of 2022.