Captain Danny McGuire has been named in Rhinos’ initial 19-man squad after missing the past two games due to a calf problem.
McGuire was sidelined just two games into his return from a knee injury sustained in Rhinos’ opening match of the season.
Brett Ferres, signed from Huddersfield in December, is also in contention to feature after five games out with a calf injury.
And Josh Walters, who has missed three games due to a damaged foot, is another addition to the initial squad.
Jordan Baldwinson, who played for Featherstone Rovers on dual-registration last week, has been included along with Brett Delaney (hamstring) and Zak Hardaker (head), who were both hurt in last Friday’s defeat at St Helens.
Carl Ablett is ruled out because of an ankle injury picked up at Langtree Park and Beau Falloon (back) also drops out.
Giants are without Craig Huby, who suffered a torn pectoral muscle in last week’s defeat at Wigan.
Kruise Leeming also drops out, but Eorl Crabtree and Jake Wardle are back in contention, along with Tyler Dickinson and Gene Ormsby.
Leeds Rhinos’ squad: Hardaker, Watkins, McGuire, Burrow, Galloway, Jones-Buchanan, Sutcliffe, Delaney, Singleton, Garbutt, Keinhorst, Achurch, Mullally, Walters, Handley, Golding, Baldwinson, Lilley, Ferres.
Huddersfield Giants’ squad: McGillvary, Cudjoe, Joe Wardle, Murphy, Brough, Crabtree, Hinchcliffe, Lawrence, Wood, Rapira, Ta’ai, Connor, Johnson, Mason, Roberts, Dickinson, Jake Wardle, Brierley, Ormsby.