Leeds-born scrum-half Danny Care has been rested for England’s summer tour to Argentina with Calum Clark included by head coach Stuart Lancaster.
Captain Chris Robshaw - who is on standby for the British and Irish Lions touring party to Australia - is also being rested, meaning Tom Wood takes over the captaincy.
Lancaster has named 11 uncapped players, including Northampton’s Clark.
They are forwards Rob Buchanan (Harlequins), Matt Kvesic (Worcester Warriors), Ed Slater (Leicester Tigers), Henry Thomas (Sale Sharks) and Billy Vunipola (London Wasps), and backs Kyle Eastmond (Bath Rugby), Jonny May (Gloucester Rugby), Joel Tomkins (Saracens), Christian Wade (London Wasps) and Marland Yarde (London Irish).
England – without the players from the Aviva Premiership final the previous day – are taking on the Barbarians at Twickenham Stadium on May 26 before playing a CONSUR XV, representing the South American nations, in Montevideo, Uruguay, on June 2, and then Tests against Argentina in Salta (June 8) and Buenos Aires (June 15).
Lancaster said: “We’re really looking forward to this tour and we’ve selected a young and exciting side which I’m sure will do the country proud in a tough series of matches.
“The key principles in selection were threefold: first and foremost to win the games but also to develop strength in depth and more options in certain positions, and to give one or two players a physical and mental break.
“We feel we’ve got the balance right and have given places to a number of players who have shone in the Aviva Premiership this season, one or two who have been on the fringes for a while, and several players who have been involved over the last year or so. This is everyone’s chance to step up.
“Tom Wood will captain the side and I am sure he will do a fantastic job, as he has the respect of all the players and management and we are looking forward to other leaders developing in the absence of some senior players.
“A few are being rested after a hard campaign but they will, of course, be considered by the British & Irish Lions should they be required.”