Sean St Ledger said: “It is another disappointing result, we got back in it and then couldn’t see it out.
“The focus now is on the last two games and getting some more points from it.”
The visitors who needed a positive result, started brightly saw a chance missed when a corner found Joey Jones, he got too much on his header though and it went over the crossbar.
They continued to press for the opener and it arrived, Charlie Carter worked his way into the area and after being given time and space, he picked the bottom right-hand corner to give the Cards the lead.
It was Woking who controlled the tempo of the match and were controlling the midfield as well.
Guiseley had their first chance when John Rooney direct from a corner, saw his attempted cross, hit the roof of the net.
Woking nearly grabbed a second with moments to go before the break when a corner found its way to Jordan Wynter, with the cross hitting him at pace, he adjusted his body to make contact but his effort hit the ground and bounced up over the crossbar.
Guiseley again saw Woking continuing to control the match going into the second-half, with Carter seeing his header well saved by Joe Green.
But the Lions got an equaliser when Dayle Southwell was found in the area, he took a touch in the area and fired his effort into the bottom right hand corner with a smart finish.
With five minutes to go Woking made their final change with Richard Orlu coming on and with his first touch he headed in from a corner to send the away support wild.
Guiseley end the home season with three wins out of 23 games.
Guiseley starting 11: Green, Nirrenold, Palmer, Flowers, Holden, Morrison (Haworth 68) Purver (Roberts 84) Hatfield, Rooney, Liburd, Southwell
Unused substitutes: Coddington, Frempah, Odejayi, Roberts
Woking starting 11: Baxter, Ramsay, Ralph, Jones, Carter, Isaac (Orlu 85) Staunton, Wynter, Ferdinand, Cook (Charles-Cook 76) Theophanous (Grego-Cox 66)
Unused substitutes: Mason, Young
Referee: Andrew Miller