Vintage Clouds, who just missed the cut for taking part in last weekend’s Randox Health Grand National at Aintree, is currently favourite for the four-mile marathon.
Stable jockey Danny Cook rides the Trevor Hemmings-owned chaser while Henry Brooke partners Straidnahan as the Bingley trainer seeks her first win in the race.
There is further West Yorkshire representation courtesy of Alzammaar from the stable of Guiseley trainer Sam England. Conditional rider Callum Bewley is in the saddle.
The 30 runners also include the Hemmings-owned Vicente who is seeking a third successive victory.
Meanwhile, Gordon Elliott, who saddled National hero Tiger Roll , is due to be represented by Fagan, although he has not been seen since chasing home Black Corton at Cheltenham in October.
Nicky Henderson, who famously has never won a Grand National in any country, runs both top weight Gold Present, owned by West Yorkshire businessman John Cotton, and Beware The Bear.
Trainer Jessica Harrington has announced the death of Irish Grand National winner Our Duke.
The eight-year-old, who won the Fairyhouse showpiece as a novice last season, suffered a heart attack.
Our Duke won six of his 13 races, amassing nearly £350,000 in career earnings.