Sheridan Smith appears as Annie and is joined by young stars Beau Gadsdon, KJ Aikens, Eden Hamilton, Austin Haynes and Zac Cudby.
John Bradley, who played Samwell Tarly in HBO fantasy epic Game Of Thrones, also joins the cast in a supporting role.
It has been shot in key locations from the original film, including Oakworth Station in Haworth, West Yorkshire, and the nearby Bronte Parsonage. The Keighley & Worth Valley Railway from the original film also features.
The Railway Children, based on a book written by E Nesbit in 1906, told the story of a mother and her three children who move to the Yorkshire countryside after their father is falsely imprisoned.
The film, released in 1970, also starred Dinah Sheridan, Bernard Cribbins, Sally Thomsett and Gary Warren.
The new film is directed by Morgan Matthew and written by Danny Brocklehurst, and also stars Sir Tom Courtenay.
The Railway Children Return opens in UK cinemas on April 1 in 2022.