The air ambulance has been sent to the scene of the closure, between junctions 46 for Colton and Garforth and 45 for Cross Green.
Debris from the lorry collided with vehicles travelling in the opposite direction
The southbound carriageway has been blocked by the accident and the northbound lanes have also been shut to allow the helicopter to land, and to allow debris to be cleared.
Traffic is being diverted and if travelling southbound you should continue travelling south down the A1(M) until you reach J42. At this point join the M62 heading westbound, continue along the M62 to re-join the M1 at Lofthouse Interchange.
Northbound traffic should exit at J44 and head east along the A639 to the A642 Oulton Junction. Join the A642 and head south to join the M62 J30, travel east to J33 and take the link road for the A1(M) northbound. Travel north to J42 and exit to join the A63 west. Continue for 6 miles to re-join the M1 at J46.
Motorists heading towards the area are advised to allow additional travelling time.