After taking two points from nine available in Championship appointments against Stoke City, Luton Town and Wigan Athletic, the relegation-threatened Reds now face a daunting trio of games against sides with aspirations of reaching the Premier League, starting with Leeds, who find themselves on the brink of promotion and ending their 16-year wait to return to the top-flight.
Despite the huge task facing his side, who also face Nottingham Forest and Brentford before the end of the season, Struber retains confidence that Barnsley - who have beaten Fulham twice already this season and drawn against West Brom on two occasions - can upset the formbook.
He said: "We have a clear game plan and this is necessary. But it is not so easy against Leeds's plan on the ball. We know that is our chance. Leeds is a very, very good team in this league, but they also have a weakness and I hope we can find a weakness in this game.
"We will search for that in my plan to give the boys a good duel.
"Especially our style means it is also not so easy for Leeds.
"They always have control of the ball from their goalkeeper and build up from their first line. (But) this is also a big chance for us through good pressing moments and good transition moments.
"We will see what Leeds do and how our execution is on these day."
Barnsley will be without midfielders Elliot Simoes and Romal Palmer for Thursday's encounter at Elland Road.