Police were called just before 5.30pm today to a house in Ashton View, Harehills.
A 34-year-old man was found with a serious head injury.
He was taken to hospital for treatment but was pronounced dead at short time later.
A 35-year-old man and a 24-year-old woman have been arrested in connection with the incident, West Yorkshire Police said.
A police cordon is in place and enquires are ongoing to establish the full circumstances.
Anyone with any information is asked to contact the police via 101 quoting log number *1379 of December 6.