The M62 Eastbound is closed between Junction 29 Leeds and Junction 30 Wakefield.
The cause is believed to be a collision between four lorries.
West Yorkshire Fire Service said: "Road traffic collision involving 4 HGV’s. 1 person trapped fire service personnel completing extrication. Police and ambulance on scene."
A spokesman for Highways England said: "All emergency services are en route to the scene.
"Please seek an alternative route and allow extra time for your journey this afternoon."