The Metropolitan Police said five men aged between 23 and 42 were injured when a car hit a number of pedestrians on Stockwell Road near the junction of Sidney Road, in south-west London, just before 3am.
None of the injured are in a critical condition.
Officers believe the collision occurred shortly after an “altercation” between the occupants of the vehicle and a number of pedestrians.
The car, a VW Golf, was abandoned at the scene and a number of occupants made off on foot, the Met said.
They are not treating it as a terrorist incident or a hate crime.
The Met said officers and the London Ambulance Service were at the scene, where the road was closed both ways between Sidney Road and Stockwell Park.
Inquiries continue, and no arrests have been made.
Anyone with information should call Lambeth CID on 101.