Highways England has announced it will close sections of the M62 overnight between junction 18 and junction 20 overnight for resurfacing.
Parts of the five-mile stretch of road near Rochdale have developed cracks and potholes during winter and closures will be in place between 10pm and 5am for a fortnight.
Only one side of the motorway will be affected each night and there will be no overnight closures during weekends.
John Lyssejko, project manager at Highways England, said: “We’ll be carrying out the resurfacing work overnight to fix the potholes and cracks that have developed on the M62 during the winter.
“Anyone who has recently driven along the stretch of motorway past Rochdale will have noticed that the road needs to be resurfaced and this work will result in smoother and safer journeys for drivers.
“We’ll be closing short stretches of the motorway overnight, Monday to Friday, at times when the motorway is at its quietest.”
Motorists will be able to follow clearly-signed diversion routes while stretches of the motorway are closed where the M62 meets the M60 and M66.
The closures are due to take place on the following dates but could be postponed if heavy rain is forecast.
M62 westbound - junctions 20-19: March 8, 9 and 16.
M62 eastbound - junctions 19-20: March 10 and 17.
M62 eastbound - junctions 18-20: March 11.
M62 eastbound - junctions 18-19: March 14.
M62 westbound - junctions 19-18: March 15.