The General Tarleton, at Ferrensby, near Boroughbridge, was forced to shut in March as a result of the pandemic.
Joint liquidators Julian Pitts and Richard Kenworthy of Begbies Traynor, who were appointed on September 30, said its closure was an "unfortunate cost" of health measures to try and control the spread of the disease.
The pub, which had featured in the Good Pub Guide, had employed 12 staff.
It was described by the Guide as a "carefully renovated" 18th-century coaching inn, more restaurant-with-rooms than pub" with a bar which also served Black Sheep and Timothy Taylors.
“Like so many hospitality businesses, the forced closure triggered by the pandemic has been absolutely devastating to the General Tarleton; and its owners, including chef John Topham, had no choice but to put the business into liquidation,” said joint liquidator Richard Kenworthy.
“With more months of uncertainty ahead and the likelihood of continued restrictions on the operation of hospitality businesses, it’s closure is an unfortunate cost of the health measures implemented to help combat the global pandemic.
"The directors really had no way to save the business and the jobs it supported; it is sad to see the end of such a popular restaurant and inn,” he added.
The assets of the business will be sold by the joint liquidators to realise funds for the benefit of the creditors that include HMRC and trade suppliers.
The inn, from which the business traded, was not owned by the company, but leased.