During the candid chat, which aired on ITV on 8 March, Harry addressed his relationship with the royal family.
The duke claimed they “literally cut me off financially” and revealed that he had money left to him by his late mother, Princess Diana, which he and Meghan were using to fend for themselves.
So, how much did Diana leave her sons?
Here is everything you need to know.
Why was Harry cut off financially?
Financial ties between Harry and Meghan and the royal family were cut in the first quarter of 2020, the duke told Oprah.
This was shortly after the pair stepped back as senior royals in January 2020, intending to split their time between the UK and North America.
Harry revealed: “I was totally cut off financially. My family cut me off.”
It has been reported that Prince Charles Harry’s father, was the one who made the decision to withdraw the couple’s private allowance, as a result of them stepping down as working royals.
Harry went on to say that was the reason he and Meghan had signed lucrative deals with entertainment giants Netflix and Spotify - thought to be worth $100million and $30million respectively.
Both deals were signed between the streaming platforms, Archewell Audio and Archewell Productions, which are Harry and Meghan’s own companies.
The Duke of Sussex explained: "All I wanted was enough money to get security and keep my family safe."
The couple claim they were forced to move to the Los Angeles home of billionaire media mogul Tyler Perry when their funding and security was withdrawn.
They are now residing in California with Archie, where they have purchased a $14.7million (£10.6million) Montecito mansion.
How much did Diana leave Harry?
Harry spoke about his late mother candidly during the chat with Oprah.
One of the things he touched on was the money Princess Diana had left him and his brother, William, after she died 23 years ago in a Paris car crash.
"Without that, we wouldn't have been able to do this," he said about the sum, referring to the family's move to California.
The duke even suggested that Diana foresaw that he would be cut off financially from the institution.
“It’s like she saw it coming and she’s been with us through this whole process,” he added.
Diana’s money came in the form of a trust fund, which both Harry and William inherited on their 30th birthdays.
The substantial sum was then invested by royal advisers, with Harry thought to have received around £10million from Diana’s fund in total.
Princess Diana also left her sons her priceless jewellery collection.
Her estate, worth £21million before inheritance tax, consisted of stocks and shares, jewellery and her multi-million pound divorce settlement from Charles, along with clothing and personal items.
Harry and William’s great-grandmother, the Queen Mother, is also thought to have left the princes around £14million in inheritance between them.
What is Prince Harry worth?
Thanks to the trust fund left by Diana and the money from other inheritances, Harry is thought to have a personal net worth of $50million (£36million).
It has previously been reported that he earned around £40,000 as a helicopter pilot during his time working in the Army.
Meanwhile, Meghan’s personal wealth is reportedly around $5million.
This sum was gained from her successful acting career and her prominent role in Suits, where she was paid $450,000 (£345,000) per series - and she starred in seven of them.
She may also receive royalties for reruns and streaming of the show.
The duchess appeared in multiple Holywood productions during her career, including Remember Me and Horrible Bosses.