Highways England have confirmed that the road will remain closed until all of the vehicle involved have been recovered.
There are long queues on the approach to the J26.
Police have confirmed they were called to the scene at about 3.30pm to reports of an overturned lorry.
All appropriate emergency services are on the scene.
It is being treated as a serious road traffic collision.
Enquires are ongoing.
In an update on Twitter, Highways England said: "#M62 J26 #ChainBar Westbound exit slip is fully closed. @WYP_RPU @YorksAmbulance @WYFRS and #TrafficOfficers dealing with a multi-vehicle road traffic collision.
"Queues on the approach to J26, please use caution on the approach. Further updates to follow shortly."
They have advised anyone wishing to access the M606 northbound to travel to Junction 25 and turn around on the M62 Eastbound back to J26.