The crash happened on Burnley Road (A646) at its junction with the Warley Wood Avenue, Luddendenfoot.
Police officers and emergecny services were called at 8.58am this morning (Thursday).
A spokesperson for West Yorkshire Police said a motorbike has been in a collision with a grey Mercedes.
The motorcyclist has suffered serious injuries and has been taken to hospital by ambulance.
Burnley Road was closed in both directions but it has now reopened.
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