Gloucestershire CCC v Yorkshire CCC: Latest updates from LV County Championship season-opener
Dawid Malan (65) and Harry Brook (56 not out) underpinned a successful chase of 211 in a minimum of 60 overs.
Yorkshire won with 10.5 overs remaining, Harry Duke finishing on 17 after George Hill had earlier stroked 36.
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Hide AdBrook and Duke saw Yorkshire home with an unbroken stand of 67.
Earlier, Gloucestershire were bowled out for 359 in their second innings, James Bracey top-scoring with a career-best 177 and Steve Patterson taking 4-43.
Yorkshire return to action on Thursday when they face Northamptonshire at Wantage Road.
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