Federer's Wimbledon reign is over
Federer, who has won the men's singles title in six of the last seven years, became the latest casualty in a tournament of shocks as he went down 6-4 3-6 6-1 6-4 to the world number 13 on a stunned Centre Court.
The result was greeted with widespread disbelief as the Swiss ace joined last year's runner-up Andy Roddick and women's second seed Venus Williams on the wayside.
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Hide AdBerdych, who had lost eight of his previous 10 meetings with Federer, becomes the first Czech to reach the semi-finals of the Wimbledon men's singles since Ivan Lendl 20 years ago and is aiming to become the first winner from his country since Jan Kodes in 1973.
Standing in his way in Friday's semi-finals will be third seed Novak Djokovic, who has beaten him in both their previous meetings.
Federer's Wimbledon record
1999: First round, lost 6-3 3-6 4-6 6-3 6-4 to Jiri Novak (Cze)
2000: First round, lost 7-5 7-5 7-6 (8/6) to Yevgeny Kafelnikov (Rus)
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Hide Ad2001: Quarter-final, lost 7-5 7-6 (8/6) 2-6 7-6 (8/6) to Tim Henman (Gbr)
2002: First round, lost 6-3 7-6 (7/2) 6-3 to Mario Ancic (Cro)
2003: Final, won 7-6 (7/5) 6-2 7-6 (7/3) against Mark Philippoussis (Aus)
2004: Final, won 4-6 7-5 7-6 (7/3) 6-4 against Andy Roddick (USA)
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Hide Ad2005: Final, won 6-2 7-6 (7/2) 6-4 against Andy Roddick (USA)
2006: Final, won 6-0 7-6 (7/5) 6-7 (2/7) 6-3 against Rafael Nadal (Spa)
2007: Final, won 7-6 (9/7) 4-6 7-6 (7/3) 2-6 6-2 against Rafael Nadal (Spa)
2008: Final, lost 6-4 6-4 6-7 (5/7) 6-7 (8/10) 9-7 to Rafael Nadal (Spa)
2009: Final, won 5-7 7-6 (8/6) 7-6 (7/5) 3-6 16-14 against Andy Roddick (USA)
2010: Quarter-final, lost 6-4 3-6 6-1 6-4 against Tomas Berdych (Cze)