The Terriers head into the game on a sensational 15-match unbeaten run, and will look to extend their fine form and boost their chances of promotion back to the top tier.
Last time out, Carlos Corberan's side stunned league leaders Fulham with a 2-1 win at Craven Cottage, which saw them bolster their position within the play-off places.
When Huddersfield last faced Cardiff, back in November, a stoppage time goal for the Welsh side saw them claim a 2-1 win, and the Terriers will be out for revenge on home turf.
Speaking after his side's win against Fulham, Corberan said: "For me the result was the consequence of a high level of personality from the players. To come to this stadium and to achieve three points you can only do this with a lot of personality.
“Against teams like them you have to attack perfectly, and then defend perfectly. The mentality shown by the team was key.
“I put this win in context, we are playing against the best team in the league and away from home – so you can’t be more excited than that. But I get satisfaction from every win.
“Every player performed to a high level. In the first half, especially, we were very good and looked very balanced. And we got a result that the incredible effort deserved, that is the best thing.”
Take a look at the latest news and transfer stories from the second tier, ahead of another busy midweek packed with fixtures:
1. Ince pledges to fix Reading's defence
Reading's interim boss Paul Ince has his first priority to shore up the team's leaky defence, as he looks to keep the struggling side in the Championship. They're currently in 21st place - just five points clear of the relegation zone. (BBC Sport) Photo: Ryan Pierse
2. Lilywhites loanee sets sights on Reds breakthrough
Preston North End loan star Sepp van den Berg has admitted that he's unlikely to have a third season at Deepdale, unless the club secure promotion. He's targeting breaking into Liverpool's first team squad for the 2022/23 campaign. (LEP) Photo: Charlotte Tattersall
3. Phillips supports Sunderland's Posh decision
Ex-Sunderland star Kevin Phillips has claimed the club made the right decision not to sign Peterborough United striker Jonson Clarke-Harris in last month. He's suggested that the rumoured asking price of £6m would have been an unwise long-term investment. (Football Insider) Photo: Harriet Lander
4. Warnock urged to take Posh job
Radio host and Peterborough United fan Adrian Durham has urged the club to consider hiring Neil Warnock as their new manager. He's claimed it would take "a miracle" to keep the side up, and that the squad "isn't fit" for the Championship. (talkSPORT) Photo: Alex Pantling