Doncaster Rovers receive bad news regarding George Miller and Harrison Biggins plus updates on Jonathan Mitchell and Ro-Shaun Williams
Miller, who has scored 13 goals this term, sustained a knee injury in last weekend's 3-1 League Two loss at Salford City and is now likely to go under the knife.
Five-goal Biggins, who has been suffering from a groin issue, is also set to undergo surgery.
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Hide AdIt is the latest issue to befall Schofield, with key loan midfielder Charlie Lakin recently ruled out for the remainder of the campaign due to a hip injury, subsequently described as a 'sickener' by the Rovers chief.


Schofield, speaking ahead of the home game with Northampton Town, said: "I'd be very surprised if we saw them (Miller and Biggins) again this season.
"With Charlie Lakin also ruled out for the season, it's a tough one, but one you have to accept as it's part and parcel of football.
"For the players as well, it is a massive disappointment and disappointing in general. To have them not available for selection is more of a challenge, I think.
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Hide Ad"It is an opportunity for the (other) players to stand and give a good account of themselves to make sure they make a positive impact."
Better news is likely to see Jonathan Mitchell return for the home encounter with the high-flying Cobblers.
The keeper has missed the club's last two games after injuring his shoulder in the second-half of the recent 2-1 win over AFC Wimbledon with the club bringing in an emergency loan signing Stuart Moore on a seven-day loan from Blackpool in time for the games at Salford and Crawley.
The loan is unlikely to be extended into a second week.
Schofield said: "We are hopeful with Mitch. He was on the pitch, albeit a very light session and we will push him a little bit more tomorrow to assess him and hopefully he will be available."
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Hide AdDefender Ro-Shaun Williams won't feature on Saturday, Schofield confirmed.
He continued: "Ro-Shaun will still be out. He has not really progressed from the running he has been doing on the ultra-G machine, so he won't be available."