Ex-Sheffield United and Hull City boss appointed manager of Bradford City's League Two rivals
However, he has now been given handed the reins permanently, penning a deal that runs until 2026.
Adkins said: “It’s an honour to take the manager’s role at a club I previously played for, and which is my hometown club.
"I have no illusions that we have work to do given our very poor start to the season, however I would not have accepted this role on a permanent basis if I was not confident that we can put it right.
"The infrastructure and support that is in place at Tranmere Rovers is top quality and with the support of the SWA it gives us a strong foundation as we look to build momentum and move up the table.”