A run of postponements over the last month means that the last time Kidderminster played was on December 28.
Caretaker manager Colin Gordon could include former player Keith Lowe, academy duo Tyrone Williams and James Hancocks and new additions Ousmane Fane and Arthur Gnahoua today.
Guiseley chief Mark Bower is uncertain if it will be a good or a bad time to travel to the National League’s basement side.
He said: “They might be well-rested and with new players who are looking to make an impression, or they might be a bit rusty with new players coming into the team who are not familiar with anyone else.
“It’s a little bit of a step into the unknown for us really,” added Bower.
Bower can call upon Anthony Dudley, who had a goalscoring return to Guiseley against Dulwich Hamlet after agreeing another loan spell from Bury.
Harrogate Town, who won 3-2 against Hednesford on January 9, their last game, host Solihull Moors in National League North.