But better news sees the return to the fray of Jamie Shackleton following an abductor problem, while Kalvin Phillips and Rodrigo came through unscathed following Monday night's game at West Ham.
Meanwhile, defender Robin Koch could feature for the under-23s against Newcastle United on Monday and take another significant step in his comeback.
The German centre-half has been out with a knee problem which flared up in the reverse fixture against Chelsea at Stamford Bridge on December 5.
Gaetano Berardi, named in a Premier League squad for the first time on Monday following a torn ACL last summer, will be in the Leeds squad again.
Providing an update on Struijk, who has struggling with a 'knock' and Hernandez, sidelined with a minor muscular problem, head coach Marcelo Bielsa commented: "Neither will be able to play."
Specifically on the condition of the former, he added: "The response I must give is the progress of his evolution will tell us when he returns.
"Given the injury Pascal has, it is not a serious injury because various players of ours have played with this injury. That's why I say it's not serious. While he is not needed urgently, I prefer he has more time to recover completely."
“Shackleton is available, Koch also, Berardi also. Rodrigo and Phillips are both good. Neither of Hernandez and Struijk will be able to play.”