Liverpool were the closest challengers to Pep Guardiola's side last campaign, finishing one point behind the champions as the title race went down to the final day.
But how is it going to play out this time around?
Data experts and bookmakers have made their predictions ahead of the new campaign as Chelsea, Tottenham Hotspur, Arsenal and Manchester United look to close the gap to last season's top two.
City have had a busy summer as they look to bolster from a position of strength with the signings of Kalvin Phillips and Erling Haaland making them the biggest spenders in the Premier League this summer.
Arsenal have forked out the third-most amount of money on transfer fees this window while Tottenham have spent just under £80m on new players.
Chelsea have spent approximately the same amount as Tottenham, with Raheem Sterling and Kalidou Koulibaly arriving at Stamford Bridge this window.
Liverpool are close behind Spurs and Chelsea with £77m paid in transfer fees as they aim to go one better than last season's second place while Manchester United have spent just £13m as they target more players. The Red Devils also secured the signing of Christen Eriksen on a free transfer on Friday.
Ahead of the upcoming campaign, we have put together how the final table will look come May based on the predictions from data experts and bookmakers...

17. 4th: Chelsea
The Blues are expected to finish in the top four as data experts rate their probability of winning the title at 5.7% while their odds of finishing top are 16/1. Photo: Getty Images

18. 3rd: Tottenham Hotspur
Spurs are tipped to finish ahead of both Chelsea and Arsenal next term as data experts rate their probability of winning the title at 6.1% while their odds of finishing top are 14/1. Photo: Getty Images

19. 2nd: Liverpool
After finishing second by point last season, data experts rate the Reds' probability of winning the title at 23.8% while their odds of finishing top are 5/2. Photo: Getty Images

20. 1st: Manchester City
After winning four of the last five titles, Man City are expected to continue their dominance as data experts rate their probability of winning the title at 59.9% while their odds of finishing top are 4/7. Photo: Getty Images