Between the Premier League and Championship, he made 218 appearances in English football before joining up with Jokanović in Qatar with Al-Gharafa.
The experience of the player looked like it would benefit United in their first season back in the Championship but the player has now left the club.
A club statement confirmed: "United can confirm an agreement has been reached to mutually terminate the contract of midfielder Adlène Guedioura.
"The Algerian international joined the Blades in September last year but injury has restricted him to just two appearances for the club.
"His departure was finalised late on Monday evening."