Striker crisis developing at Rotherham as another forward suffers injury blow
The 29-year-old, who has netted 15 times this season, sustained an injury to his quad and was withdrawn after 80 minutes as the Millers were beaten by MK Dons.
It follows a more serious injury to fellow forward Will Grigg last month, with the Sunderland loanee likely to be out until the end of the season.
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Hide AdAn initial assessment of Ladapo's injury would see him miss league games against Wycombe Wanderers, Lincoln City and Shrewsbury Town as well as Wednesday's Papa John's Trophy semi-final tie at Hartlepool United.
"Freddie looks like he is going to be out for a couple of weeks, potentially," confirmed Warne.
The trip to Hartlepool could see Warne hand a debut to Georgie Kelly, who has been improving his fitness since joining Rotherham from League of Ireland side Bohemians, where he was in a part-time environment.
Saturday's defeat to MK Dons may change Warne's plans for what team he fields on Wednesday.
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Hide AdThe game could see the returns of Rarmani Edmonds-Green and Mickel Miller, who have both been sidelined by hamstring problems.
"It might change my thought process for Wednesday night as we need a good performance and we need a win," added Warne.
"I need the same thing at Wycombe. Going to Hartlepool on a Wednesday night is not an ideal fixture for us but I respect the competition. We are going to have to look at who is fit and ready."