The 29-year-old is synonymous with the London 2012 venue after clinching heptathlon gold on ‘Super Saturday’, when British team-mates Mo Farah and Greg Rutherford also topped the podium.
Ennis-Hill will return to the Queen Elizabeth Olympic Park in July, taking part in the Diamond League meet as she builds towards the Rio Games in 2016 having missed the majority of last season after giving birth to her first child.
“I am really looking forward to the Sainsbury’s Anniversary Games in the Olympic Stadium,” she said.
“My race schedule is starting to take shape and it will be good to compete and get a sense of where I am in my return to competing.
“My main goal this season is to be as competitive as possible with the long term goal being the Rio Olympics.
“Diamond League meetings always have the best athletes in the world so I’m sure this will be a good test for me.
“I want to perform well being back on the big stage in London but I will be realistic as 2015 is about the challenge of getting back to competitive shape after having my little boy and ultimately making the necessary progression to be at my best for Rio.”
Ennis-Hill will take part in the two-day Diamond League meeting on July 24 and 25, with the Sainsbury’s IPC Athletics Grand Prix Final taking place on July 26.