England lose Dom Young and Morgan Knowles for final two Tests against Tonga
Young announced himself on the international stage with nine tries in five games at last year's World Cup but must wait for his next cap after a frustrating return to England.
St Helens loose forward Morgan Knowles will also miss Saturday's match in Huddersfield and next week's clash at Headingley with a thumb injury sustained in the 22-18 win in the first Test.
England boss Shaun Wane has opted against calling up replacements.
"Despite losing two players, I am still extremely confident that the squad I have selected is strong enough to win this series against Tonga," he said.
“Tom Johnstone and Tommy Makinson both impressed me at the weekend and we have another terrific winger in Matty Ashton who is pushing to force his way into the side.
“We’ve also got a number of forwards who can slot into the team in Morgan’s absence – Tyler Dupree, Robbie Mulhern and Liam Farrell all didn’t feature this past weekend and could come in."