His work, titled Remember You Cannot Look At The Sun Or Death For Very Long, appeared on the Piccadilly Lights screen in Piccadilly Circus.
It is also being shown on screens in New York, Los Angeles, Seoul and Tokyo.
The video shows an animated sunrise and was created on Hockney’s iPad.
Discussing the artwork Hockney, 83, previously said: “What does the world look like? We have to take time to see its beauty. That’s what I hope my work will encourage people to do when they see it on the large screens.”
He had left Bradford in 1959 to attend the Royal College of Art in London, but it was in Los Angeles where he established himself in the mid-1960s as a leading light in the new pop art movement.
The video is being shown every evening throughout May in Piccadilly Circus.