42nd East Bakehouse already has branches in Beverley, Leeds and Lincoln.
Owner Lee Edwards, who lives in Beverley, began the business as an Instagram brand, with postal deliveries of items such as brownies and cookies for customers all over the UK.
He opened his first outlet in Lincoln Market in the summer of 2019 and sites in the Corn Exchange in Leeds city centre and St Mary's Yard in Beverley followed in 2020.
The dog-friendly chain specialises in baked treats, breakfasts and brunches.
Mr Edwards will open the new outlet on Church Street, opposite All Saints Church, in Helmsley this spring.
Six members of staff will also be recruited.
The business will predominantly operate as a takeaway but will have a limited amount of indoor and outdoor seating that can be used when restrictions are lifted.
Mr Edwards said: "The reason we have chosen Helmsley is because it’s a lovely vibrant market town and fits our business ethos - we always like to offer something different to what an area already has."
The business still has a significant social media presence with over 31,000 followers on Instagram.