Figures released by NHS England show 45 deaths were recorded in the 24 hours to 4pm on Tuesday April 6.
Since April 28 2020, NHS England and NHS Improvement also started to report the number of patient deaths where there has been no Covid-19 positive test result but it is documented as a direct or underlying cause of death in the death certification process.
Some 13,202 deaths have been recorded in hospitals across Yorkshire and the North East since the start of the pandemic.
Deaths were recorded at the following hospital trusts in Yorkshire and the Humber:
Barnsley Hospital NHS Foundation Trust: 1
Calderdale and Huddersfield NHS Foundation Trust: 1
The Government said a further 45 people in England had died within 28 days of testing positive for Covid-19.
It brings the UK total to 149,168.
The Government also said that, as of 9am on Tuesday, there had been a further 2763 lab-confirmed cases in the UK.