In a normal year, the heritage line's trains would begin running in April following the winter break, but the Covid-19 exit roadmap has required opening to be delayed until Saturday May 15.
The railway will be operating two trains to Whitby every day, as well as an intermediate service between Pickering and Grosmont.
Restrictions will be in place until at least the summer holidays, with pre-booking essential and all trains are 'end to end' with set departures and return times for passengers. The Pickering - Grosmont service will allow passengers to explore Levisham, Goathland and Grosmont stations.
Tickets go on general sale from April 26 and anyone who has pre-booked for 2020 will be given priority re-booking from April 19.
All passengers aged over 16 willbe required to take part in Track and Trace, adhere to social distancing and wear face coverings.
Tickets are available for journeys up to June 20, after which fresh timetables will be prepared in accordance with the latest regulations.
NYMR general manager Chris Price said: “It was a huge relief when the government announced its roadmap, which now enables the railway to plan and prepare for when it can re-open. It will be great to see the staff and volunteers preparing the engines, stations, shops and tea rooms, ready to welcome passengers once more”.
The first Pullman dining train will run on May 20, with a new spring lunch menu available. Pullman services operate Thursday-Sunday each week during the season.
Holiday accommodation at Grosmont, Goathland and Levisham stations will open from May 15.
Several major events planned for this spring and summer have been cancelled, but the railway hopes to run the autumn steam gala in September and the Santa Specials at Christmas.
Due to maintenance, the line will be closed from June 4-8.