Officers were called to A1033 Patrington Road, East Yorkshire between Ottringham and Patrington after receiving reports that a car had collided with a bike.
According to Humberside police, it is believed that a red Nissan Duke was travelling towards Patrington when it veered onto the wrong side of the road and collided with a bike.
The Nissan Duke is then reported to have left the road and come to a stop in a nearby ditch.
The man riding the bike suffered fatal injuries and died at the scene.
One man was arrested on suspicion of causing death by dangerous driving and driving over the legal limit.
He remains in police custody while officers enquiries continue.
Officers are now appealing for anyone who was in the vicinity with dash cam footage, or who saw the collision, to contact the police on non-emergency number 101 and quote log 652 of June 26