The crash took place on the A1246 between Fairburn and Brotherton, near Ferrybridge power station, at 2.40pm on Wednesday.
The biker's red, white and blue motorcycle collided with a grey estate car.
The man was pronounced dead at the scene but his age has not been released by police.
The driver stopped at the scene.
Both vehicles were travelling in the same direction towards Brotherton.
North Yorkshire Police are now appealing for witnesses or anyone with dashcam footage to come forward.
Anyone with information should contact North Yorkshire Police on 101, or email [email protected] quoting reference 12210097908.