The pair, who have been estranged from their family since moving to America, smiled and waved at the crowds as they entered the cathedral, and then seemed to be happily greeting friends and family once they took their seats. But there were no pictures of the couple with either Prince William or Prince Charles as they seemed to be seated away from the leading Royals.
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Meghan, the Duke and Duchess of Sussex, arrives for the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry arrives for the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. Photo: Getty Images
. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Harry and his wife Meghan, the Duke and Duchess of Sussex, enter Saint Paul's Cathedral for the National Service of Thanksgiving for The Queen's reign. Photo: Getty Images
17. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince William and Catherine, the Duke and Duchess of Cambridge, wave as they arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral in London. Photo: Getty Images
18. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Zara Tindall and her husband Mike Tindall arrive to the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral in London. Photo: Getty Images
19. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prince Charles, Prince of Wales arrives at the National Service of Thanksgiving at St Paul's Cathedral. Photo: Getty Images
20. National Service of Thanksgiving for The Queen at Saint Paul's Cathedral
Prime Minister Boris Johnson and his wife Carrie Symonds arrive to attend the National Service of Thanksgiving for The Queen's reign at Saint Paul's Cathedral. The PM was met with a mixture of boos and cheers. Photo: Getty Images