The crash happened at about 5.30am today (Tuesday), at Stump Cross near Boroughbridge.
Police said the crash happened in a lay by on the on the A168, and involved a lorry and a black Skoda Fabia car.
The road is now closed south of the crash scene at the Marton cum Grafton junction towards Wetherby.
Motorists are being urged to avoid the area.
Anyone with information about the collision is asked to contact police on 101, quoting NYP-21112-17-0038 when passing on information.