The crash, which happened on the eastbound carriageway heading towards Leeds at around 2.30pm on March 16, involved six vehicles, including four HGV lorries and a Ford Fiesta.
Initial police enquiries suggest most of the vehicles crashed after the Fiesta struck barriers and rebounded onto the carriageway which caused following vehicles to brake suddenly.
Four people were treated for injuries and a 39-year-old man from Huddersfield was pronounced dead a short time after the crash.
A 37-year-old man is still in hospital with serious injuries.
The crash closed the M62 in both directions for most of the afternoon and into the evening, and Yorkshire Air Ambulance, West Yorkshire Police and Yorkshire Ambulance crews all attended the scene.
A statement from West Yorkshire Police said: "Police are appealing for information following a fatal road traffic collision on the M62 motorway. The incident happened on the Eastbound carriageway at about 2.30pm yesterday (Tuesday), close to Junction 22, involving six vehicles.
"Four people were treated for injuries. One of those, a 39-year-old man from Huddersfield, was pronounced deceased a short time later.
"A 37-year old male remains in hospital with serious injuries.
"Initial enquiries suggest most of the vehicles were in collision after a Ford Fiesta struck barriers and rebounded on to the carriageway, which caused following vehicles to brake suddenly.
"The Major Collision Enquiry Team is investigating the collision and is appealing for anyone with dash cam footage which may assist to contact 101 or via the website www.westyorkshire.police.uk/101LiveChat quoting log 1041 of 16 March."