The result leaves Carlos Corberan's side lying perilously in 19th place, seven points above the relegation zone, and should Rotherham United pick up points from their two games in hand, Huddersfield could well become embroiled in a battle to avoid a bottom-three finish.
Speaking in the wake of the defeat, the Terriers boss said: "Football is not about how many chances you create it is about how many chances you take. We did not make the most of those chances.
“Preston used their opportunities well and they were much better than us in that area.”
Huddersfield will look to bounce back tomorrow night, when they take on fellow strugglers Birmingham City in a must-win game at the John Smith's Stadium.
The Terriers will be out for revenge following the two sides' last meeting, where a 90th minute Lukas Jutkiewic goal saw Birmingham snatch a late win at St. Andrew's.
Here are today's biggest transfer stories and the latest team news involving Huddersfield Town and the rest of the Championship, ahead of the midweek action:
“Preston used their opportunities well and they were much better than us in that area.”
5. Kane reveals Blades approach
QPR midfielder Todd Kane has revealed he nearly joined Sheffield United two seasons ago, during his time at Chelsea, but saw the move fall through due to the Blues focusing their attentions on capturing Gonzalo Higuain on loan from Juventus. (The 72) Photo: Warren Little
6. Warnock spreads net wide in striker search
Middlesbrough boss Neil Warnock has revealed he's determined to sign a new striker this summer, and hinted that he'll be exploring options "on the continent", as he looks to unearth a hidden gem in Europe during the next transfer window. (Hartlepool Mail) Photo: Stu Forster
7. Rovers set for pitch overhaul
Blackburn Rovers are preparing to splash the cash on a new £2m overhaul of their playing surface, with a grass/artificial surface combination and improved under-soil heating set to revitalise their stadium facilities. (Lancashire Telegraph) Photo: Jan Kruger
8. QPR take Gunners youngster on trial
QPR have brought Arsenal teenager Luke Plange in on a trial, as they weigh up a potential move for the 18-year-old striker this summer. He's likely to be released by the Gunners at the end of the current campaign. (West London Sport) Photo: Julian Finney