Defender Joachim Andersen was forced to miss Palace's 2-1 defeat against Aston Villa as the Eagles saw their seven-game unbeaten run come to an end.
Manager Patrick Viera has confirmed that the Danish defender will not be fit in time for tomorrow's trip to Elland Road.
Palace do have some positive news on the injury front, however, after Eberechi Eze came off the bench with an hour gone against Villa.
The attacking midfielder had not played since mid-May after suffering an Achilles injury before the end of last season.
Palace will be without vice-captain James McArthur because of a hamstring problem.