The two sides played out a Premier League classic in their opening day fixture last season, with a ding-dong battle at Anfield finishing 4-3 to the Reds, as the likes of Jack Harrison and Patrick Bamford found themselves on the score sheet for the Whites.
The Whites' game following a hectic international break, which has seen both Leeds' Patrick Bamford and Kalvin Phillips in action for England.
Discussing the latter, following last night's 1-1 draw with Poland, Three Lions boss Gareth Southgate said: “He's been excellent. The way he has taken to international football, it hasn't surprised us because what we'd seen with Leeds.
“Even in the Championship, we felt could convert into our team. We felt he could play an important role with us. To play in the enormity of the matches he did in the summer and play as well as he did is massive credit to him.
“He's a very, very good player and he's been a really important part of this - we're 16 games unbeaten [in regulation time] now and he's been a huge part of that.”
Meanwhile, down in the second tier, it's set to be a lively weekend of action, with Yorkshire sides Huddersfield Town, Hull City, Sheffield United and Barnsley all in action.
Take a look at the latest news round-up involving Yorkshire sides and more, as the build-up to the weekend's action continues:
5. Lions boss not looking at free agents
Millwall boss Gary Rowett has claimed he has no intentions of bringing in any further signings, despite second tier sides still being able to sign free agents. He's insisted he's focusing on getting his existing crop of players back to full fitness. (Football League World)
Photo: Jacques Feeney
6. Sibley eyes number ten role
Derby County midfielder Louis Sibley has revealed he's revelling in the fluid midfield role he has under Wayne Rooney, and has identified the number ten role as his favoured spot. He earned his first England U20 cap against Romania earlier in the week. (Club website)
Photo: Alex Burstow
7. Forest eye ex-Shakhtar goal machine
Nottingham Forest are believed to be closing in on a move for free agent forward Facundo Ferreyra. The ex-Shakhtar Donetsk and Benfica forward spent the 2014/15 season on loan with Newcastle United, but failed make single appearance. (Sport Witness)
Photo: Alex Caparros
8. Tykes duo head to Denmark
Barnsley have confirmed the departure of duo Rudi Pache and Steve Simpson, who have both been snapped up on permanent deals by Danish second tier side Esbjerg fB. There new club are bottom of the table, with no wins in seven games. (Club website)
Photo: George Wood