The Reds crashed out of the Champions League last night, and the Whites will be looking to inflict more pain on Jurgen Klopp's side by claiming all three points in their encounter.
Speaking after their loss, Klopp immediately turned his attention to next Monday night, and said: "Monday night against Leeds is the next challenge," Klopp reflected after defeat to Real Madrid.
“The Champions League is very important for this club for different reasons. We can now concentrate on the Premier League. That is what we will do.
“[Leeds are] leading in all the physical stats in the league - we have to run. We have to work our socks off pretty much to get anything but we will try to prepare for it.”
Meanwhile, down in the Championship, a number of Yorkshire's sides remained embroiled in the relegation battle, with Sheffield Wednesday, Huddersfield Town and Rotherham United all in danger of the drop with just a handful of matches left to play.
Here are today's biggest transfer stories and the latest team news involving Leeds United, Barnsley and a number of other sides from Yorkshire and beyond, as the reaction to the build-up to the weekend's action continues:
. LUTON, ENGLAND - APRIL 05: Daryl Dike of Barnsley celebrates after scoring their side's first goal during the Sky Bet Championship match between Luton Town and Barnsley at Kenilworth Road on April 05, 2021 in Luton, England. Sporting stadiums around the UK remain under strict restrictions due to the Coronavirus Pandemic as Government social distancing laws prohibit fans inside venues resulting in games being played behind closed doors. (Photo by Julian Finney/Getty Images)
Leeds United transfer news (Photo by Julian Finney/Getty Images) Photo: Julian Finney
. Forest target to cost £3m
Nottingham Forest transfer target Jacob Murphy is set to cost around £3m this summer. Southampton and Watford look to be the front-runners to sign the Newcastle United winger, who cost them £12m back in 2017. (Football Insider) Photo: STU FORSTER
5. Swans eye Seagulls starlet
Swansea City have been linked with a move for Brighton & Hove Albion starlet Marc Leonard. The Scotland youth international has impressed for the Seagulls' U23 side this season, and will be a free agent in the summer. (Daily Record) Photo: Ian MacNicol
6. Potters target signs new deal
Stoke City's hopes of signing Motherwell right-back Stephen O'Donnell this summer look to be over, after he signed a fresh contract extension. The ex-Luton Town man has been capped 18 times by Scotland's senior side. (The 72) Photo: ANDY BUCHANAN
7. Rams striker issues rallying cry
Derby County ace Colin Kazim-Richards has claimed it's a "sink or swim" situation for the Rams, as they head into their final five games of the season. They're four points clear of the drop-zone, but Rotherham have three games in hand over them. (Club website) Photo: Laurence Griffiths
8. Holden takes Stoke role
Ex-Bristol City manager Dean Holden has taken up a new position as the assistant manager of Stoke City. Potters boss Michael O'Neil has lauded the 41-year-old's record for developing younger players. (Club website) Photo: Justin Setterfield