The last time the two sides met, back in December, the Red Devils romped to a 6-2 win at Old Trafford, and Marcelo Bielsa's side will be out for revenge, as they also look to secure a top-half finish in what has been a stellar return to the Premier League this season.
Speaking after their 1-1 draw with Liverpool on Monday, before the so-called European Super League folded last night, the Leeds boss gave his view on the highly-controversial competition proposals, and contended: “The president of the club (Andrea Radrizzani) puts his thought forward to limit the power of these big clubs. This is something to celebrate.
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“Of course there are different teams that are more important than others but they should be conscious that we need each other. Because football has always a view that's more commercial now, it's natural that in the world of businesses and looking only at the economic aspect the ones that produce the most demand the majority of it.
Spurs chairman Daniel Levy's decision to sack Jose Mourinho is rumoured to have been down to fears over a mass exodus of their star players this summer, including the likes of Harry Kane and Dele Alli. (Eurosport)
“That's common in the world of business, but football is not only a business. But before or after it was going to happen because football belongs to everybody even if there are owners, the real owners of football are the ones who love the badge. Without them football would disappear.
“Any decision that attacks all these people, all the fans of football, and that privileges only one sector is staking the future.”
Here are today's biggest transfer stories and the latest team news involving Leeds United and the rest of the Premier League, as the reaction to the midweek action continues:
Arsenal are believed to be in "advanced talks" with Brighton goalkeeper Matt Ryan over a permanent switch to the Emirates Stadium. He could be available for a fee of around £5m. (Football Insider)
Aston Villa are the latest side to take an interest in Manchester United midfielder Jesse Lingard. The England international has been in red hot form during his loan spell with West Ham, and looks set to be the subject of a bidding war this summer. (Mirror)
West Brom look set to dig their heels in and rebuff interest from West Ham in their goalkeeper Sam Johnston. Although, manager Sam Allardyce has admitted keeping the player could be tricky if the side are relegated. (Express & Star)
Ex-Leeds United man Noel Whelan has urged the Whites to pursue a move for Rangers' £10m-rated midfielder Glen Kamara. He's claimed the Finland international would be a perfect fit for the Whites, amid rumours he'll sign a new Gers deal. (Football Insider)
Bayern Munich look set to rival the likes of Manchester United and Arsenal for Rennes starlet Eduardo Camavinga. The 18-year-old is set to leave his club this summer, and could cost close to £40m. (ESPN)
Ex-Spurs boss Jose Mourinho has been named as a shock potential contender to become the next Celtic manager. He was sacked by the north London club less than a week before their Carabao Cup Final clash against Man City. (The Sun)
Real Betis have emerged as potential candidates to sign Manchester United defender Eric Bailly. The Ivory Coast international has struggled for game time this season, with Harry Maguire and Victor Lindelof becoming the first-choice centre-back duo. (Team Talk)
Aston Villa have been named as favourites to land Chelsea striker Tammy Abraham in the summer. The Blues forward could leave the club at the end of the season, after falling out of favour with manager Thomas Tuchel. (SkyBet)
Besiktas look set to sell striker Cyle Larin this summer, despite the player netting 19 goals so far this season. West Ham and Everton are both said to be keen on the £8m-rated star. He's previously been heavily-linked with Leeds. (FotoMac)