The last time the two sides met, back in December, the Red Devils romped to a 6-2 win at Old Trafford, and Marcelo Bielsa's side will be out for revenge, as they also look to secure a top-half finish in what has been a stellar return to the Premier League this season.
Speaking after their 1-1 draw with Liverpool on Monday, before the so-called European Super League folded last night, the Leeds boss gave his view on the highly-controversial competition proposals, and contended: “The president of the club (Andrea Radrizzani) puts his thought forward to limit the power of these big clubs. This is something to celebrate.
“Of course there are different teams that are more important than others but they should be conscious that we need each other. Because football has always a view that's more commercial now, it's natural that in the world of businesses and looking only at the economic aspect the ones that produce the most demand the majority of it.
“That's common in the world of business, but football is not only a business. But before or after it was going to happen because football belongs to everybody even if there are owners, the real owners of football are the ones who love the badge. Without them football would disappear.
“Any decision that attacks all these people, all the fans of football, and that privileges only one sector is staking the future.”
Here are today's biggest transfer stories and the latest team news involving Leeds United and the rest of the Premier League, as the reaction to the midweek action continues:
1. Mourinho sacked to keep Levy
Spurs chairman Daniel Levy's decision to sack Jose Mourinho is rumoured to have been down to fears over a mass exodus of their star players this summer, including the likes of Harry Kane and Dele Alli. (Eurosport) Photo: GLYN KIRK
2. Gunners close in on Ryan
Arsenal are believed to be in "advanced talks" with Brighton goalkeeper Matt Ryan over a permanent switch to the Emirates Stadium. He could be available for a fee of around £5m. (Football Insider) Photo: IAN KINGTON
3. Villa could join Lingard chase
Aston Villa are the latest side to take an interest in Manchester United midfielder Jesse Lingard. The England international has been in red hot form during his loan spell with West Ham, and looks set to be the subject of a bidding war this summer. (Mirror) Photo: DAVE ROGERS
4. Baggies keen to keep Johnston
West Brom look set to dig their heels in and rebuff interest from West Ham in their goalkeeper Sam Johnston. Although, manager Sam Allardyce has admitted keeping the player could be tricky if the side are relegated. (Express & Star) Photo: MICHAEL STEELE