Manchester City's dramatic 3-2 defeat against Tottenham Hotspur on Saturday night reignited the battle for the title, putting extra emphasis on tonight's meeting on Merseyside.
Liverpool are likely to opt for a strong line-up as they seek a victory that could move them within three points of Pep Guardiola's side.
Jurgen Klopp may have one eye on Sunday's Carabao Cup final against Chelsea at Wembley and the Reds boss may opt to rotate a few bodies but is still likely to field a formidable side against United.
Marcelo Bielsa's team selection will be dictated by injuries within his squad, with Robin Koch the latest name sidelined after suffering a head injury against Manchester United on Sunday afternoon.
Liverpool rested a number of players as they defeated Norwich City on Saturday afternoon but will be without Diogo Jota and Roberto Firmino this evening.
Kalvin Phillips and Leeds skipper Liam Cooper are not expected to return until next month as they recover from respective hamstring injuries, while Patrick Bamford (foot) remans a long-term absentee.
Taking all of that into account, we have taken a closer look at how both sides could line up at Anfield this evening.