Liverpool were the closest challengers to Pep Guardiola's side last campaign, finishing one point behind the champions as the title race went down to the final day.
But how is it going to play out this time around?
Data experts and bookmakers have made their predictions ahead of the new campaign as Chelsea, Tottenham Hotspur, Arsenal and Manchester United look to close the gap to last season's top two.
City have had a busy summer as they look to bolster from a position of strength with the signings of Kalvin Phillips and Erling Haaland making them the biggest spenders in the Premier League this summer.
Arsenal have forked out the third-most amount of money on transfer fees this window while Tottenham have spent just under £80m on new players.
Chelsea have spent approximately the same amount as Tottenham, with Raheem Sterling and Kalidou Koulibaly arriving at Stamford Bridge this window.
Liverpool are close behind Spurs and Chelsea with £77m paid in transfer fees as they aim to go one better than last season's second place while Manchester United have spent just £13m as they target more players. The Red Devils also secured the signing of Christen Eriksen on a free transfer on Friday.
Ahead of the upcoming campaign, we have put together how the final table will look come May based on the predictions from data experts and bookmakers...
5. 16th: Southampton
The Saints finished 15th last campaign, five points above the relegation zone. Data experts have rated their probability of winning the title at 0.1% while their odds of finishing top are 500/1. Photo: Getty Images
6. 15th: Crystal Palace
The Eagles enjoyed a comfortable campaign clear of relegation trouble in Patrick Vieira's first season in charge last term. Data experts have rated their probability of winning the title at 0.1% while their odds of finishing top are 500/1. Photo: Getty Images
7. 14th: Leeds United
The Whites avoided relegation on the final day of last season with victory in Brentford. Data experts have rated their probability of winning the title at 0.1% while their odds of finishing top are 500/1. Photo: Getty Images
8. 13th: Wolves
Wolves finished comfortably in 10th position last campaign in Bruno Lage's first year at the helm. Data experts have rated their probability of winning the title at 0.1% while their odds of finishing top are 250/1. Photo: Getty Images