The Owls are still waiting for a first win under new manager Darren Moore, and were ultimately undone by a piece of magic from Todd Cantwell in Sunday afternoon's 2-1 defeat to Norwich City.
That result leaves Wednesday winless in seven and seven points adrift of safety with 11 games to go.
By contrast, Town are unbeaten in their last three, and picked up three valuable points against QPR at the weekend in a 1-0 win.
The Terriers are 18th in the table, eight points above the drop zone.
Looking ahead to Wednesday night’s clash, Prutton believes that they can further their survival hopes with another important point.
The pundit predicts a 1-1 draw.
The last meeting between the two sides ended in a 2-0 Huddersfield win back in December.