The Reds are 2-0 ahead on aggregate, with an own goal from a Jordan Henderson cross and a goal from Sadio Mane giving them the edge heading into the second leg.
How can I watch?
The fixture will be broadcast on BT Sport 2, with coverage starting at 7pm for the game which kicks off at 8pm.
BT Sport customers can watch the action as part of their subscription. Alternatively, a monthly pass is available and can be used on two devices. It costs £25 and can be cancelled at anytime.
Liverpool forward Roberto Firmino will miss the Champions League semi-final second leg against Villarreal as he has not fully recovered from a foot injury.
The Brazil international has missed the last four matches and, while he will travel with the squad to Spain, he is not in contention.
Forward Divock Origi returns after illness ruled him out at the weekend, while centre-back Ibrahima Konate, Thiago Alcantara, Fabinho and Mohamed Salah – all rested for Saturday’s win at Newcastle – are set to return.