George Ford continues to miss out despite his outstanding form at the heart of Leicester’s revival with Farrell, Marcus Smith and uncapped Bath prospect Orlando Bailey included as fly-halves.
There is no place for versatile back Elliot Daly despite his recovery from the stress fracture that forced him to sit out a successful autumn, and his Saracens colleagues Mako and Billy Vunipola also remain in international exile.
A fifth ever-present from the 2019 World Cup squad, and up until now a key member of Eddie Jones’s back-row, has been frozen out in flanker Sam Underhill.
The uncapped Bailey, Alfie Barbeary, Ollie Chessum, Tommy Freeman, Ollie Hassell-Collins and Luke Northmore continue Jones’s overhaul of his England squad as he builds for France 2023.