The nationally-renowned event marks the opening round of the HSBC UK National Circuit Series.
Harry Tanfield, who rides for Qhubeka Assos on the World Tour has not competed since abandoning the Tour of Romandie at the end of April.
He is on the startlist in Otley tonight along with brother Charlie who is traditionally more of a track cyclist but is set to ride for British team Canyon DHB Sungod.
Also due in West Yorkshire tonight is Doncaster veteran Graham Briggs of Clancy Briggs Cycling Academy, Sheffield’s Joey Walker of Crimson Orientation and Joseph Pidcock – the younger brother of Ineos Grenadiers prospect Tom – who rides for Groupama FDJ.
The Otley Grand Prix begins at 8.30pm with the evening commencing at 6pm when the flag drops on the youth races.
The Chevin Cycles Classic follows at 6.40pm and the women’s race at 7.30pm.
Dame Sarah Storey for her own team Storey Racing is the headline act, alongside a stellar field including local riders Gabriella Shaw of CAMS-Basso and Abi Smith (Team Breeze) and Sophie Thackray (UK Scott).