Wane must omit three players from the 20-man squad he selected at the start of this week.
There are five potential debutants in Wane's squad in Matty Ashton, Joe Batchelor, Matty Lees, Jake Wardle and Jack Welsby.
Michael McIlorum, Mike McMeeken, Kallum Watkins and Ryan Hall, meanwhile, have all returned to the international fold.
It is only Wane's third game in charge of the national team, with the former Wigan Warriors boss overseeing last year's clash with the All Stars and the Test match against France.
After losing to the All Stars 12 months ago, England will be out to redress the balance.
Here, The Yorkshire Post predicts England's line-up for Saturday's clash at the Halliwell Jones Stadium.
Michael McIlorum, Mike McMeeken, Kallum Watkins and Ryan Hall, meanwhile, have all returned to the international fold.